Grapefruit and grapefruit juice may connect with sildenafil and result in unwanted side effects. Keep away from using grapefruit solutions although using sildenafil.
Sildenafil should not be taken by people that just take nitrates including nitroglycerin (glycerin trinitrate), as this might end in a significant and probably deadly fall in hypertension.[three]
The maximum advised dosing frequency is at the time per day. Make sure you inform your health practitioner about all of the medicines you're taking and another professional medical circumstances as your dose may possibly must be altered.
Make contact with your doctor or search for crisis medical interest if your erection is distressing or lasts extended than 4 several hours. A protracted erection (priapism) can hurt the penis.
The primary indication of sildenafil is remedy of erectile dysfunction (lack of ability to maintain a satisfactory erection to complete intercourse).
The wellbeing information contained herein is provided for academic reasons only and is not meant to exchange discussions with a Health care company. All choices concerning affected person care need to be made with a Health care provider, considering the exceptional qualities with the affected individual.
You should carry this listing along with you every time you stop by a doctor or If you're admitted into a healthcare facility. Additionally it is vital details to carry along with you in case of emergencies.
-Individuals should really seek out speedy professional medical interest from the party of the sudden loss of eyesight in a single or the two eyes though getting this drug.
Sildenafil is broken down during the liver by hepatic metabolism working with cytochrome p450 enzymes, largely CYP450 3A4(main route), but additionally by CYP2C9 (minor route) hepatic isoenzymes. The most important product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity to the PDE receptors, about 40% of that of sildenafil. Hence, the metabolite is to blame for about twenty% of sildenafil's action.
Generally speak to your healthcare supplier to be certain the knowledge exhibited on this web page relates to your personal situation.
Sildenafil as well as other PDE5 inhibitors are utilised off-label to ease vasospasm and deal with significant ischemia and ulcers in fingers and toes for those with secondary Raynaud's phenomenon;[nine][ten] these medicine have reasonable efficacy for decreasing the frequency and period of vasospastic episodes.
In the event you miss out on a dose of Revatio, take the missed dose as soon as you don't forget. PDE-5 Skip the missed dose if it is almost time for the up coming scheduled dose. Usually do not take further medication to help make up the missed dose.
Some medicines can cause unwanted or risky outcomes when applied with sildenafil. Convey to your medical professional about your latest medicines, In particular riociguat (Adempas).
Those people using protease inhibitors are advised to limit their usage of sildenafil to no multiple 25 mg dose each 48 several hours.[two] Other drugs that interfere Using the metabolism of sildenafil incorporate erythromycin and cimetidine, both equally of which can also cause extended plasma fifty percent-life amounts.